2019顾孝诚讲座——刘光慧 | 活动-资讯-知识分子

2019顾孝诚讲座——刘光慧 | 活动

2019/10/16
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2019年11月2日 厦门大学生命科学学院

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2019 GU XIAOCHENG LECTURE


The 2019 GU XIAOCHENG LECTURE is awarded to Dr. Guang-hui Liu of Institute of Zoology,Chinse Academy of Sciences.
The Gu Xiaocheng lecture award was established by the Gu Xiaocheng Memorial Fund in 2012. The lectureship recognizes young investigators showing promises to become future leaders inlife science research,especially those who work in China.
Dr.Guang-hui Liu received his Ph.D. from Institute of Biophysics,Chinese Academy of Sciences,China in 2007. He did postdoctoral research in The Scripps Research Institute (2007-2009)and Salk Institute for Biological Studies(2009-2012)in USA. Under the National 1000 Young Talents Program,Dr. Liu became a member of Institute of Biophysics,Chinese Academy of Sciences,in 2012. He recently moved his laboratory to Institute of Zoology,Chinese Academy of Sciences.
In his study of aging mechanism,Dr. Liufirst discovered that SIRT6 forms a complex with both nuclear factor erythroid2-related factor 2 (NRF2) and RNA polymerase II. This complex could transactivate NRF2-regulated antioxidant genes. This activation may induce overexpression of HO-1 in SIRT6-null human mesenchymal stem cells to rescue premature cellular attrition. Furthermore, a SIRT6-null cynomolgus monkey(Macaca fascicularis)model was created by using a CRISPR-Cas9-based approach.SIRT6 deficiency led to histone hyperacetylation at the imprinting control region ofH19,which results in CTCF recruitment and upregulation of H19. This maysuggest that SIRT6 functions are related to human perinatal lethality syndrome.In another study, Dr. Liu found that DiGeorge syndrome critical region 8(DGCR8) is important in maintaining heterochromatin organization and attenuating aging. Overexpression of DGCR8 alleviated mouse osteoarthritis,which points to a potential drug target for osteoarthtitis.
Dr. Liu is recognized for his original contributions to the understanding of molecular mechanisms of stem cell aging,and stem cell based gene therapy. His work is fundamental to the future development of translational medicine for aging related diseases. He has comeon stage as a new leader in the field of aging research.
Dr. Liu will present his latest work inthe 11th Ray Wu Symposium at School of Life Sciences,Xiamen University,on November 2, 2019.

顾孝诚讲座


2019年顾孝诚讲座授予中国科学院动物研究所刘光慧博士。


顾孝诚讲座奖由顾孝诚纪念基金会于2012年设立。该奖鼓励生命科学研究领域有潜力成为未来学科领袖的青年科学家,特别是那些学成回国的青年学者。


刘光慧博士于2007年获得中国科学院生物物理研究所理学博士学位。他曾在美国斯克利普斯(Scripps)研究所(2007-2009)和索尔克(Salk)生物学研究(2009-2012)从事博士后研究。2012年,刘博士获得中组部青年千人计划支持并就职于中国科学院生物物理研究所。他最近将实验室迁到了中国科学院动物研究所。

在对衰老机制的研究中,刘博士首先发现 SIRT6 与核因子红细胞2相关因子2(NRF2)和 RNA 聚合酶II形成复合物。这种复合物可以逆转 NRF2 调节的抗氧化基因。这种激活可能诱导 SIRT6 缺失的人骨髓间充质干细胞中 HO-1 的过度表达,以挽救细胞的早衰。此外,利用 CRISPR-C9 方法建立了一个 SIRT6 零食蟹猴模型。SIRT6 缺乏导致 H19 印记控制区组蛋白高乙酰化,导致 CTCF 募集和H19 上调。这可能提示 SIRT6 功能与围产儿死亡综合征有关。在另一项研究中,刘博士发现 DiGeorge 综合征临界区8(DGCR8)在维持异染色质组织和延缓衰老方面有很重要的作用。DGCR8 的过度表达减轻了小鼠骨关节炎,提示了骨关节炎的潜在药物靶点。

刘博士在干细胞衰老的分子机制研究和干细胞的基因治疗领域做出了重要的原创性研究工作。他的工作对老年相关疾病转化医学的未来发展具有重要意义。他已成为老龄化研究领域新的领军人物。

刘博士将于2019年11月2日在厦门大学生命科学学院第十一届吴瑞纪念研讨会上介绍他的最新研究成果。

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